ReeCure

Causes

Parkinsons disease was first described in England in 1817 by Dr. James Parkinson. The disease most often develops after the age of 50. It is one of the most common nervous system disorders of the elderly. Sometimes Parkinsons disease occurs in younger adults, but is rarely seen in children. It affects both men and women.

In some cases, Parkinsons disease occurs in families. When a young person is affected, it is usually because of a form of the disease that runs in the family.

Nerve cells use a brain chemical called dopamine to help control muscle movement. Parkinsons disease occurs when the nerve cells in the brain that make dopamine are slowly destroyed. Without dopamine, the nerve cells in that part of the brain cannot properly send messages. This leads to a loss of muscle function and the damage gets worse with time. Exactly why the brain cells waste away is unknown.

Parkinsons in children may occur because the nerves are not as sensitive to dopamine but Parkinsons is rare in children.

The term "parkinsonism" refers to any condition that involves the types of movement changes seen in Parkinsons disease. Parkinsonism may be caused by other disorders (such as secondary parkinsonism) or certain medications.

Symptoms

The disorder may affect one or both sides of the body and how much function is lost can vary. Symptoms may be mild at first. For instance, the patient may have a mild tremor or a slight feeling that one leg or foot is stiff and dragging.

Symptoms include:

• Automatic movements (such as blinking) slow or stop
• Constipation
• Difficulty swallowing
• Drooling
• Impaired balance and walking
• Lack of expression in the face (mask-like appearance)
• Muscle aches and pains (myalgia)
• Problems with movement
  • Difficulty starting or continuing movement, such as starting to walk or getting out of a chair
  • Loss of small or fine hand movements (writing may become small and difficult to read and eating becomes harder)
  • Shuffling gait
  • Slowed movements
• Rigid or stiff muscles (often beginning in the legs)
• Shaking, tremors
  • Tremors usually occur in the limbs at rest, or when the arm or leg is held out
  • Tremors go away during movement
  • Over time, tremor can be seen in the head, lips, tongue and feet
  • May be worse when tired, excited or stressed
  • Finger-thumb rubbing (pill-rolling tremor) may be present
• Slowed, quieter speech and monotone voice
• Stooped position

Other symptoms:

• Anxiety, stress and tension
• Confusion
• Dementia
• Depression
• Fainting
• Hallucinations
• Memory loss
• Oily skin (seborrhea)

An examination may show:

• Difficulty starting or finishing voluntary movements
• Jerky, stiff movements
• Muscle atrophy
• Parkinsons tremors
• Variation in heart rate

Reflexes should be normal and tests may be needed to rule out other disorders that cause similar symptoms.

Medications control symptoms, mostly by increasing the levels of dopamine in the brain. At certain points during the day, the helpful effects of the medication often wears off and symptoms can return.

Your doctor needs to change the:

• Type of medication
• Dose
• Amount of time between doses
• How the medications are taken

Work closely with your doctors and therapists to adjust the treatment program. Never change or stop taking any medications without talking with your doctor.

Many medications can cause severe side effects, including hallucinations, nausea, vomiting, diarrhea and delirium. Monitoring and follow-up by the health care provider is important.

Eventually, symptoms such as stooped posture, frozen movements and speech difficulties may not respond very well to drug treatment.

Medications used to treat symptoms of Parkinsons disease are:

• Levodopa (L-dopa), Sinemet, levodopa and carbidopa (Atamet)
• Pramipexole (Mirapex), ropinirole (Requip), bromocriptine (Parlodel)
• Selegiline (Eldepryl, Deprenyl), rasagiline (Azilect)
• Amantadine or anticholinergic medications - to reduce early or mild tremors
• Entacapone - to prevent the breakdown of levodopa

Lifestyle changes that may be helpful for Parkinsons disease:

• Good general nutrition and health
• Exercising, but adjusting the activity level to meet changing energy levels
• Regular rest periods and avoiding stress
• Physical therapy, speech therapy and occupational therapy
• Railings or banisters placed in commonly used areas of the house
• Special eating utensils
• Social workers or other counseling services to help you cope with the disorder and get assistance (such as Meals-on-Wheels)

Less commonly, surgery may be an option for patients with very severe Parkinsons disease who no longer respond to many medications. These surgeries do not cure Parkinsons, but may help some patients:

• In deep brain stimulation (DBS), the surgeon implants electrical stimulators in specific areas of the brain to help with movement.
• Another type of surgery destroys brain tissues that cause Parkinsons symptoms.

We, at ReeCure offer you therapy using stem cells using our proprietary technology.

These stem cells could be of various types viz. Hematopoietic (CD 34+), Mesenchymal stem cells (MSCs) that are processed and isolated using Good Manufacturing (GMP) and Good Lab Practices (GLP) and in accordance with AABB standards. These stem cells are procured from various sources including bone marrow, cord blood fat etc. as per the requirement of the patient.

After years of extensive research and systematic compilation and collation of relevant data (through its research division), ReeLabs is now supremely confident of not only reversing the disease process of the affected patient but also improving the quality of life manifold. Stem cells produced by ReeLabs are completely safe, non-toxic, easy to administer and totally devoid of side effects with an excellent probability of homing and engraftment with parent cell, tissue or organ. The eminent panel of scientists, and researchers at ReeLabs work exhaustively to design accurate treatment protocols that have yielded excellent results in most cases.

Stem cell therapy has shown to form dopamine producing cells in the substantia nigra of the brain. Stem cell therapy is extremely helpful in patients not responding to conventional treatment.

Stem cell therapy definitely improves the quality of life & helps getting rid of most of the manifestations of Parkinsons disease.